This study uses molecular dynamics simulations to examine how the orientation of Stone Thrower Wales defects impacts the mechanical properties of graphene. Different types of STW defects are introduced in linear and angular orientations along the zigzag and armchair directions of graphene. The results provide insights into how the mechanical properties of graphene, such as strength and flexibility, can be tailored by controlling the placement and structure of defects. Understanding these effects could inform applications of defect-engineered graphene in flexible electronics and nanodevices.