Biology:CHRNB3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene. This gene has been identified as a candidate for predisposition to tobacco dependence.

See also

• Nicotinic acetylcholine receptor

Further reading

• "Ion-channel assembly.". Trends Neurosci. 18 (6): 280–7. 1995. doi:10.1016/0166-2236(95)93915-K. PMID 7571003. 
• "Nicotinic acetylcholine receptors: from structure to brain function". Reviews of Physiology, Biochemistry and Pharmacology. 147. 2003. 1–46. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. 
• Willoughby JJ; Ninkina NN; Beech MM et al. (1993). "Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit". Neurosci. Lett. 155 (2): 136–9. doi:10.1016/0304-3940(93)90691-D. PMID 7690916. 
• "Mapping of the human nicotinic acetylcholine receptor beta 3 gene (CHRNB3) within chromosome 8p11.2". Genomics 21 (2): 460–1. 1994. doi:10.1006/geno.1994.1300. PMID 8088849. 
• Elliott KJ; Ellis SB; Berckhan KJ et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617. 
• "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–14. 1997. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220. 
• "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand) 43 (3): 433–42. 1997. PMID 9193799. 
• "A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor". J. Biol. Chem. 273 (25): 15317–20. 1998. doi:10.1074/jbc.273.25.15317. PMID 9624109. 
• Sato KZ; Fujii T; Watanabe Y et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173. 
• "Stoichiometry of human recombinant neuronal nicotinic receptors containing the β3 subunit expressed in Xenopus oocytes". J. Physiol. 529 Pt 3 (Pt 3): 565–77. 2001. doi:10.1111/j.1469-7793.2000.00565.x. PMID 11118490. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• Boorman JP; Beato M; Groot-Kormelink PJ et al. (2004). "The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors". J. Biol. Chem. 278 (45): 44033–40. doi:10.1074/jbc.M211719200. PMID 12912995. 
• Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 

External links

• CHRNB3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CHRNB3 genome location and CHRNB3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.