Biology:FCGR3A

Generic protein structure example

Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene. It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules.

Further reading

• "Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells". Proceedings of the National Academy of Sciences of the United States of America 87 (6): 2274–8. March 1990. doi:10.1073/pnas.87.6.2274. PMID 2138330. Bibcode: 1990PNAS...87.2274A. 
• "The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23". Immunogenetics 32 (3): 183–6. 1990. doi:10.1007/BF02114971. PMID 2146219. 
• "Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils". The Journal of Clinical Investigation 84 (5): 1688–91. November 1989. doi:10.1172/JCI114350. PMID 2478590. 
• "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG". Proceedings of the National Academy of Sciences of the United States of America 86 (3): 1013–7. February 1989. doi:10.1073/pnas.86.3.1013. PMID 2521732. Bibcode: 1989PNAS...86.1013P. 
• "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms". Proceedings of the National Academy of Sciences of the United States of America 86 (13): 5079–83. July 1989. doi:10.1073/pnas.86.13.5079. PMID 2525780. Bibcode: 1989PNAS...86.5079S. 
• "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions". The Journal of Experimental Medicine 170 (2): 481–97. August 1989. doi:10.1084/jem.170.2.481. PMID 2526846. 
• "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein". Nature 333 (6173): 568–70. June 1988. doi:10.1038/333568a0. PMID 2967436. Bibcode: 1988Natur.333..568S. 
• "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Experimental Hematology 22 (7): 599–606. July 1994. PMID 7516890. 
• "Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase". Journal of Immunology 155 (4): 2085–95. August 1995. doi:10.4049/jimmunol.155.4.2085. PMID 7543538. 
• "Human glomerular mesangial cells express CD16 and may be stimulated via this receptor". Kidney International 46 (6): 1627–34. December 1994. doi:10.1038/ki.1994.462. PMID 7700021. 
• "Specificity of signal transduction through CD16, TCR-CD3 and BCR receptor chains containing the tyrosine-associated activation motif". International Immunology 6 (9): 1383–92. September 1994. doi:10.1093/intimm/6.9.1383. PMID 7819147. 
• "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions". The Journal of Biological Chemistry 270 (3): 1350–61. January 1995. doi:10.1074/jbc.270.3.1350. PMID 7836402. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells". Immunology and Cell Biology 72 (1): 87–96. February 1994. doi:10.1038/icb.1994.13. PMID 8157290. 
• "Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells". Journal of Immunology 151 (12): 6794–800. December 1993. doi:10.4049/jimmunol.151.12.6794. PMID 8258691. 
• "Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells". European Journal of Immunology 23 (10): 2488–97. October 1993. doi:10.1002/eji.1830231017. PMID 8405050. 
• "A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa". Journal of Immunology 156 (8): 2948–55. April 1996. doi:10.4049/jimmunol.156.8.2948. PMID 8609432. 
• "Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene". The Journal of Biological Chemistry 271 (48): 30755–64. November 1996. doi:10.1074/jbc.271.48.30755. PMID 8940055. 
• "Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype". Blood 90 (3): 1109–14. August 1997. doi:10.1182/blood.V90.3.1109. PMID 9242542. 
• "The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms". Blood Coagulation & Fibrinolysis 23 (1): 45–50. January 2012. doi:10.1097/mbc.0b013e32834d7ce3. PMID 22024796. 
• "Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma". Internal Medicine Journal 42 (10): 1113–9. October 2012. doi:10.1111/j.1445-5994.2011.02587.x. PMID 21883784. 

External links

• Overview of all the structural information available in the PDB for UniProt: P08637 (Low affinity immunoglobulin gamma Fc region receptor III-A) at the PDBe-KB.