Biology:GPR177
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G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene[1] that encodes a receptor for Wnt proteins in Wnt-secreting cells.[2]
Wntless was shown to be a cargo for the retromer complex.[2] It has been found essential for hair follicle induction.[3]
A homozygous missense mutation in the WLS gene was identified in Zaki syndrome.[4]
References
- ↑ "Entrez Gene: GPR177 G protein-coupled receptor 177". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79971.
- ↑ 2.0 2.1 "Retromer retrieves wntless". Developmental Cell 14 (1): 4–6. January 2008. doi:10.1016/j.devcel.2007.12.014. PMID 18194646.
- ↑ "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis". The Journal of Investigative Dermatology 133 (4): 890–8. April 2013. doi:10.1038/jid.2012.407. PMID 23190887.
- ↑ Chai, Guoliang; Szenker-Ravi, Emmanuelle; Chung, Changuk; Li, Zhen; Wang, Lu; Khatoo, Muznah; Marshall, Trevor; Jiang, Nan et al. (2021-09-29). "A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion" (in en). New England Journal of Medicine. doi:10.1056/NEJMoa2033911. https://www.nejm.org/doi/10.1056/NEJMoa2033911.
Further reading
- "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells". Cell 125 (3): 509–22. May 2006. doi:10.1016/j.cell.2006.02.049. PMID 16678095.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research 13 (10): 2265–70. October 2003. doi:10.1101/gr.1293003. PMID 12975309.
- "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene 22 (21): 3307–18. May 2003. doi:10.1038/sj.onc.1206406. PMID 12761501.
See also
- GPR177+receptor,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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