Biology:TWSG1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene.[1][2] The protein is a binding protein for bone morphogenetic proteins, similar to Chordin.[3] The Twisted gastrulation gene is expressed in the extraembryonic tissues during organogenesis, and in certain adult tissues such as the lymph nodes, kidneys, liver, and lungs.[4]
References
- ↑ "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling". Nature 410 (6827): 475–8. Mar 2001. doi:10.1038/35068572. PMID 11260715.
- ↑ "Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57045.
- ↑ "The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling.". Nature 405 (6788): 757–63. 2000. doi:10.1038/35015500. PMID 10866189. Bibcode: 2000Natur.405..757O.
- ↑ Graf, D.; Timmons, P. M.; Hitchins, M.; Episkopou, V.; Moore, G.; Ito, T.; Fujiyama, A.; Fisher, A. G. et al. (July 2001). "Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation". Mammalian Genome 12 (7): 554–560. doi:10.1007/s0033501-0005-x. ISSN 0938-8990. PMID 11420619. https://pubmed.ncbi.nlm.nih.gov/11420619/. Retrieved 6 March 2023.
Further reading
- "The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development.". J. Exp. Med. 196 (2): 163–71. 2002. doi:10.1084/jem.20020276. PMID 12119341.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development.". Development 131 (2): 413–24. 2004. doi:10.1242/dev.00946. PMID 14681194.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway.". EMBO J. 24 (7): 1397–405. 2005. doi:10.1038/sj.emboj.7600615. PMID 15775969.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes.". Blood 109 (7): 2944–52. 2007. doi:10.1182/blood-2006-03-006510. PMID 17164348.
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