Chemistry:Dextrothyroxine
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| Trade names | Choloxin |
| Other names | D-3,5,3',5'-tetraiodothyronine |
| AHFS/Drugs.com | Multum Consumer Information |
| Pregnancy category |
|
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C15H11I4NO4 |
| Molar mass | 776.874 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Dextrothyroxine (trade name Choloxin) is a dextrorotary isomer of thyroxine.[1] It saw research as a cholesterol-lowering drug[2] but was pulled due to cardiac side-effects. It increases hepatic lipase which in turn improves utilization of triglycerides and decreases levels of lipoprotein(a) in blood serum.[3]
See also
References
- ↑ "Dextrothyroxine (Code C61719)". National Cancer Institute. 2011-11-14. https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C61719.
- ↑ "Comparison of effectiveness of thyrotropin-suppressive doses of D- and L-thyroxine in treatment of hypercholesterolemia". The American Journal of Medicine 77 (3): 475–81. September 1984. doi:10.1016/0002-9343(84)90107-4. PMID 6475988.
- ↑ "D-thyroxine reduces lipoprotein(a) serum concentration in dialysis patients". Journal of the American Society of Nephrology 9 (1): 90–6. January 1998. doi:10.1681/ASN.V9190. PMID 9440092.
 |  |
