Chemistry:Fenbufen
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Short description: Nonsteroidal anti-inflammatory drug, now withdrawn
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Formula | C16H14O3 |
| Molar mass | 254.285 g·mol−1 |
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| Melting point | 186 °C (367 °F) |
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Fenbufen is a nonsteroidal anti-inflammatory drug used to treat pain.[1]
Fenbufen is a member of the propionic acid derivatives class of drugs.[2]
It was introduced by American Cyanamid under the trade name Lederfen in the 1980s. Due to liver toxicity, it was withdrawn from markets in the developed world in 2010.[3][4]: 370, 383–384
As of 2015 it was available in Taiwan and Thailand under several brand names.[5]
Preparation
Fenbufen can be synthesized by acylation of biphenyl with succinic anhydride under Friedel-Crafts conditions.[6]
References
- ↑ "Single dose oral fenbufen for acute postoperative pain in adults". The Cochrane Database of Systematic Reviews 2009 (4): CD007547. October 2009. doi:10.1002/14651858.CD007547.pub2. PMID 19821427.
- ↑ "Non-steroidal anti-inflammatory analgesics other than salicylates". Drugs 32 (Suppl 4): 27–45. 1986. doi:10.2165/00003495-198600324-00004. PMID 3552584.
- ↑ "Deleted products 2010". Monthly Index of Medical Specialities (MIMS). Haymarket Media Group Ltd.. http://www.mims.co.uk/deleted-products-2010/article/978347.
- ↑ "Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists. Chapter 22". Drug-Induced Liver Disease (3rd ed.). Academic Press. 2013. ISBN 978-0-12-387818-2.
- ↑ "International listings for fenbufen". Drugs.com. https://www.drugs.com/international/fenbufen.html.
- ↑ "An Improved Synthesis of Fenbulen". Organic Preparations and Procedures International 27 (5): 550–552. October 1995. doi:10.1080/00304949509458497.
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