Chemistry:Gliquidone
From HandWiki
Short description: Chemical compound
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| Trade names | Glurenorm |
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| Routes of administration | Oral (tablets) |
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| Bioavailability | High (Tmax = 2–3 hours) |
| Metabolism | Extensive hepatic |
| Onset of action | 1–1.5 hours |
| Excretion | Biliary (95%), renal (5%) |
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| Formula | C27H33N3O6S |
| Molar mass | 527.64 g·mol−1 |
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Gliquidone (INN, sold under the trade name Glurenorm) is an anti-diabetic medication in the sulfonylurea class.[1] It is classified as a second-generation sulfonylurea. It is used in the treatment of diabetes mellitus type 2. It is marketed by the pharmaceutical company Boehringer Ingelheim (Germany).
Contraindications
- Allergy to sulfonylureas or sulfonamides
- Diabetes mellitus type 1
- Diabetic ketoacidosis
- Patients that underwent removal of the pancreas
- Acute porphyria
- Severe liver disease accompanying with liver insufficiency
- Several conditions (e.g., infectious diseases or major surgical intervention), when insulin administration is required
- Pregnancy or breastfeeding[2]
Pharmacokinetics
Gliquidone is fully metabolized by the liver. Its metabolites are excreted virtually completely with bile (even with long-term administration), thus allowing the use of medication in diabetic patients with kidney disease and diabetic nephropathy.[2]
References
- ↑ "Gliquidone contributes to improvement of type 2 diabetes mellitus management: a review of pharmacokinetic and clinical trial data". Drugs in R&D 7 (6): 331–7. 2006. doi:10.2165/00126839-200607060-00002. PMID 17073516.
- ↑ 2.0 2.1 "Glurenorm (gliquidone) 30 mg Tablets, for Oral Use. Full Prescribing Information" (in ru). Boehringer Ingelheim. http://grls.rosminzdrav.ru//InstrImgMZ/PN/P%20N014529_01/2.INS/014529_002.gif.
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