Pragmatic trials are trials that are designed to compare treatment options in a real-world setting, as opposed to explanatory trials that test a physiological or clinical hypothesis, typically to develop new drugs or other treatments. Trials can be pragmatic with regards to several features, such as the way sites and patients are recruited, the choice of outcomes, the interventions and their delivery etc. Pragmatic Trials This NEJM paper gives more information on pragmatic trials: http://www.nejm.org/doi/full/10.1056/NEJMra1510059
1. How to receive information on the KCE Trials programme?...
KCE Trials Panel Group of experts who give advice on and prioritisation of clinical topics for their importance to patients and the healthcare system. These same experts may provide additional advice during the call for proposals or development and evaluation of proposals to address these questions or topics. Belgian Coordinating Centre (BCC)
There is an important demand for clinical trials to fill existing evidence gaps and to advance healthcare. Alongside international and EU funded initiatives (such as those mapped through the ACT EU initiative), the possibilities for non-commercial sponsor to obtain funding for clinical trials in Belgium have expanded over the past years.
Conflict of Interest principles
Conflict of Interest for Advisory boards
Clinical Research Transparency Policy
KCE policy on re-use of study participant data
Investigator-led workstream SOP
