Compare the Top Secure Email Gateway Software in the USA as of January 2026

What is Secure Email Gateway Software in the USA?

Secure email gateways protect organizations from email-based threats such as phishing, malware, spam, and data breaches. They analyze incoming and outgoing messages to detect suspicious content, malicious attachments, and unauthorized data sharing. These gateways enforce email security policies, filter harmful traffic, and provide encryption to safeguard sensitive communications. Many platforms also integrate with cloud email services like Microsoft 365 and Google Workspace to extend protection across hybrid environments. Ultimately, secure email gateways help maintain compliance, protect confidential information, and ensure safe, reliable business communication. Compare and read user reviews of the best Secure Email Gateway software in the USA currently available using the table below. This list is updated regularly.

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    Zoho Mail
    Secure email hosting for your business. Host your business email on a secure, encrypted, privacy-guaranteed, and ad-free email service. Zoho Mail's data centers have top-notch security and surveillance, with a reliable 99.9% uptime. Benefit from secure email hosting that supports encryption both at rest and end-to-end, along with S/MIME message encryption. Create a domain for your business and set up custom email addresses for users. Unique and professional email addresses give your company the visibility and authenticity it deserves. Zoho Mail's powerful Control Panel is the admin's go-to place for all settings, configuration, and customization. Add users, manage group aliases, set up policies to moderate business email content, and more. Retain emails across your organization for a specified period to comply with company standards and to counter legal attacks. e-Discovery helps discover such retained emails quickly.
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    Starting Price: $2.00/month/user
  • 2
    Microsoft Exchange
    Work smarter with business-class email and calendaring. Exchange helps you collaborate on your critical documents and gives you a focused inbox that prioritizes important messages and adapts to your work style, so you can get more done–faster. Get access to a more personalized inbox with helpful features and a smarter, more organized way to view and interact with email. Search enhancements give you faster and more complete results. With Add-ins, get powerful customization and extensibility, which connect you to modern services and internal line-of-business applications. Organize your time with a calendaring system that goes beyond basic scheduling of appointments and commitments. Automatically capture events from email such as flights and hotel reservations, and get suggestions about where to meet based on your location. Microsoft Exchange Online offers a hosted email service for business. Exchange Online helps protect your information with advanced capabilities.
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    LuxSci

    LuxSci

    Lux Scientiae

    LuxSci provides HIPAA-compliant web and email communications services. LuxSci creates uniquely secure and customizable enterprise-grade environments and solutions that enable organizations to confidently meet their specific business and security needs at scale. LuxSci’s HIPAA-compliant email and web solutions are HITRUST certified and include: • Secure High Volume Sending for delivering massive volumes of transactional and marketing emails. • Secure SMTP Connector for encrypting outbound emails sent from Microsoft 365 and Google Workspace. • Secure Email Marketing platform for creating and sending marketing campaigns with ePHI. • Secure Email Hosting for reliable and secure day-to-day business email. • Fully managed Secure Web and Database Hosting for web applications that require compliance. • Secure Forms to safely collect and store sensitive information. LuxSci provides a full suite of secure technology for companies requiring compliant web and email services.
    Starting Price: $4 per/user/month
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