Alzheimer's Disease Pathogenesis - Core Concepts, Shifting Paradigms and Therapeutic Targets

Suzanne De La Monte

doi:10.5772/951

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Alzheimer's Disease Pathogenesis - Core Concepts, Shifting Paradigms and Therapeutic Targets

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Academic Editor

Suzanne M. De La Monte

Brown University,
United States of America

Published 12 September 2011

Doi 10.5772/951

ISBN 978-953-307-690-4

eBook (PDF) ISBN 978-953-51-4437-3

Number of pages 704

Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of t...

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Indexed in the Book Citation Index (BKCI) in Web of Science Core Collection™

Edited Volume and chapters are indexed in

1. Alzheimer ́s Disease – The New Actors of an Old Drama

By Mario Álvarez Sánchez, Carlos A. Sánchez Catasús, Ivonne Pedroso Ibañez, Maria L. Bringas and Arnoldo Padrón Sánchez

2,657

2. Pathophysiology of Late Onset Alzheimer Disease

By Ahmet Turan Isik and M. Refik Mas

2,768

3. Expression and Cerebral Function of Amyloid Precursor Protein After Rat Traumatic Brain Injury

By Tatsuki Itoh, Motohiro Imano, Shozo Nishida, Masahiro Tsubaki, Shigeo Hashimoto, Akihiko Ito and Takao Satou

2,932

4. Key Enzymes and Proteins in Amyloid-Beta Production and Clearance

By Cecília R A Santos, Isabel Cardoso and Isabel Gonçalves

3,256

5. Transporters in the Blood-Brain Barrier

By Masaki Ueno, Toshitaka Nakagawa and Haruhiko Sakamoto

3,338

6. Contribution of Multivesicular Bodies to the Prion-Like Propagation of Lesions in Alzheimer’s Disease

By Valérie Vingtdeux, Luc Buée and Nicolas Sergeant

2,312

7. Pathological Stages of Abnormally Processed Tau Protein During Its Aggregation into Fibrillary Structures in Alzheimer’s Disease

By Francisco García-Sierra, Gustavo Basurto-Islas, Jaime Jarero-Basulto, Hugo C. Monroy-Ramírez, Francisco M. Torres Cruz, Hernán Cortés Callejas, Héctor M. Camarillo Rojas, Zdena Kristofikova, Daniela Ripova, José Luna-Muñoz, Raúl Mena, Lester I. Binder and Siddhartha Mondragón-Rodríguez

2,597

8. Structure and Toxicity of the Prefibrillar Aggregation States of Beta Peptides in Alzheimer’s Disease

By Angelo Perico, Denise Galante and Cristina D’Arrigo

2,802

9. Structural and Toxic Properties of Protein Aggregates: Towards a Molecular Understanding of Alzheimer's Disease

By Lei Wang and Silvia Campioni

2,832

10. The Role of Glycogen Synthase Kinase-3 (GSK-3) in Alzheimer’s Disease

By Miguel Medina and Jesús Avila

3,520

11. Pin1: A New Enzyme Pivotal for Protecting Against Alzheimer’s Disease

By Kazuhiro Nakamura, Suk Ling Ma and Kun Ping Lu

2,075

12. Selectivity of Cell Signaling in the Neuronal Response Based on NGF Mutations and Peptidomimetics in the Treatment of Alzheimers Disease

By Kenneth E. Neet, Sidharth Mahapatra, Hrishikesh M. Mehta

2,527

13. Advances in MicroRNAs and Alzheimer’s Disease Research

By Francesca Ruberti, Silvia Pezzola and Christian Barbato

3,624

14. Role of Mitochondria in Alzheimer ́s Disease

By Genaro Genaro Gabriel Ortiz, Fermín Pacheco-Moisés, José de Jesús García-Trejo, Roció E. González-Castañeda, Miguel A. Macías-Islas, José A. Cruz-Ramos, Irma E. Velázquez-Brizuela, Elva D. Árias Merino and Alfredo Célis de la Rosa

3,469

15. Oxidative Stress in Alzheimer’s Disease: Pathogenesis, Biomarkers and Therapy

By Alejandro Gella and Irene Bolea

4,901

16. Impact of Oxidative - Nitrosative Stress on Cholinergic Presynaptic Function

By Stefanie A.G. Black and R. Jane Rylett

2,430

17. Metals Involvement in Alzheimer’s Disease Pathogenesis

By Rosanna Squitti and Carlo Salustri

2,902

18. Alzheimer’s Disease and Metal Contamination: Aspects on Genotoxicity

By P.D.L. Lima, M.C. Vasconcellos, R.C. Montenegro and R.R. Burbano

4,924

19. Glucose Metabolism and Insulin Action in Alzheimer’s Disease Pathogenesis

By Domenico Bosco, Massimiliano Plastino, Antonio Spanò, Caterina Ermio and Antonietta Fava

3,269

20. Insulin Resistance, Cognitive Impairment and Neurodegeneration: Roles of Nitrosamine Exposure, Diet and Lifestyles

By Suzanne de la Monte, Ming Tong and Jack R. Wands

3,039

21. The Relations Between the Vitamins and Alzheimer Dementia

By Emel Koseoglu

3,506

22. Hypotension in Subcortical Vascular Dementia, a New Risk Factor – Wasn’t It Hypertension?

By Rita Moretti, Francesca Esposito, Paola Torre, Rodolfo M. Antonello and Giuseppe Bellini

2,504

23. Autophagy-Derived Alzheimer’s Pathogenesis

By Daijun Ling and Paul M. Salvaterra

3,459

24. Plasmalogen Deficit: A New and Testable Hypothesis for the Etiology of Alzheimer’s Disease

By Paul L. Wood, M. Amin Khan, Rishikesh Mankidy, Tara Smith and Dayan B. Goodenowe

3,661

25. Gangliosides as a Double-Edged Swordin Neurodegenerative Disease

By Akio Sekigawa, Masayo Fujita, Kazunari Sekiyama, Yoshiki Takamatsu, Jianshe Wei and Makoto Hashimoto

2,943

26. Structure Based 3D-QSAR Studies on Cholinesterase Inhibitors

By Zaheer ul Haq and Reaz Uddin

2,879

27. Tau Oligomers as Potential Drug Target for Alzheimer Disease (AD) Treatment

By Rakez Kayed

2,849

28. In Silico Design of Preventive Drugs for Alzheimer’s Disease

By Arpita Yadav and Minakshi Sonker

3,177

29. Protective Roles of the Incretin Hormones Glucagon-Like Peptide-1 and Glucose-Dependent Insolinotropic Polypeptide Hormones in Neurodegeneration

By Christian Hölscher

2,904

IMPACT OF THIS BOOK AND ITS CHAPTERS

90,055 Total Chapter Downloads

3,400 Total Chapter Views

25 Crossref Citations

73 Dimensions Citations

55 Web of Science Citations

6 Altmetric Score

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