Home > Authors and editors

Preeti Dabas

St. Jude Children's Research Hospital United States of America

Dr. Preeti Dabas, a motivated scientific professional, grew up in India and earned her Ph.D. from Guru Gobind Singh Indraprastha University in Delhi, India, where she focused on yeast genetics, molecular biology, biochemistry, and biophysical techniques. She conducted her postdoctoral research at St. Jude Children’s Research Hospital in Memphis, USA, specializing in gene expression, signal transduction, DNA repair, epigenetics, stem cell biology, and translational therapeutics, as well as hematopoietic stem cell health in development and disease. Dr. Dabas has authored publications in leading journals, including Science, Science Translational Medicine, Nucleic Acids Research, and IUBMB Life, and has contributed multiple review articles and book chapters. She also serves as an academic editor and coeditor of international scientific volumes. Her research achievements have been recognized by Marquis Who’s Who in America and multiple competitive fellowships.

2books edited

1chapters authored

Latest work with IntechOpen by Preeti Dabas

Gene Expression - From Code to Cure offers a comprehensive and forward-looking exploration of how modern molecular biology is transforming our understanding of disease and redefining therapeutic possibilities. From gene editing and RNA-based therapies to DNA repair mechanisms and epigenetic regulation, this book presents a unified view of the molecular processes that govern health, aging, and disease. This book integrates gene editing, cellular and RNA-based therapies, DNA repair biology, and epigenetic regulation into a unified framework that bridges fundamental science with clinical innovation. The first section introduces readers to modern genetic therapies, tracing the evolution of genome-editing technologies from early discoveries to advanced CRISPR-based platforms. It further surveys the rapidly expanding landscape of gene, cell, and RNA therapies, highlighting their growing impact in treating both monogenic and complex disorders. The second section focuses on genomic integrity and aging, examining how DNA damage, repair mechanisms, and epigenetic alterations shape cellular function over time. Special attention is given to nonhomologous end joining (NHEJ), a critical yet imperfect DNA repair pathway, and its role in cancer, immunodeficiency, neurodegeneration, and emerging therapeutic strategies. The final section explores epigenetic inheritance and metabolic regulation of gene expression, revealing how chromatin dynamics and metabolic cues influence immune memory, cellular identity, and intergenerational information transfer. Together, these chapters emphasize that gene expression is not static but dynamically shaped by molecular, environmental, and metabolic signals. By integrating these interconnected disciplines, Gene Expression - From Code to Cure provides a clear roadmap for translating molecular insights into transformative medical interventions. Designed for researchers, clinicians, students, and advanced learners, this book serves as both an authoritative reference and an inspiring vision of how decoding life at the molecular level can lead to cures once thought impossible.

Gene Expression

Gene Expression - From Code to Cure

Edited by Preeti Dabas

Books edited

Noncoding RNA

Noncoding RNA - The Dark Matter of the Genome

Edited by Preeti Dabas

Chapters authored

Transcription Elongation Factors in Health and Disease

By Preeti Dabas

Gene expression is a complex process that establishes and maintains a specific cell state. Transcription, an early event during the gene expression, is fine-tuned by a concerted action of a plethora of transcription factors temporally and spatially in response to various stimuli. Most of the earlier research has focused on the initiation of transcription as a key regulatory step. However, work done over the last two decades has highlighted the importance of regulation of transcription elongation by RNA Pol II in the implementation of gene expression programs during development. Moreover, accumulating evidence has suggested that dysregulation of transcription elongation due to dysfunction of transcription factors can result in developmental abnormalities and a broad range of diseases, including cancers. In this chapter, we review recent advances in our understanding of the dynamics of transcription regulation during the elongation stage, the significance of transcriptional regulatory complexes, and their relevance in the development of potential accurate therapeutic targets for different human diseases.

Part of the book: Gene Expression

Related collaborators

Fumiaki Uchiumi

Tokyo University of Science , Japan

Parvaiz Yousuf

Ja Yil Lee

Ulsan National Institute of Science and Technology , Korea, South

Uma Siangphoe

Tjahjadi Robert Tedjasaputra

Internal Medicine Department, Tarakan General Hospital Jakarta, Jakarta Indonesia

Mochammad Hatta

Biology Molecular and Immunology Laboratory, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM.10, Makassar, Indonesia

Muhammad Nasrum Massi

Agussalim Bukhari

Na Young Cheon

Ulsan National Institute of Science and Technology , Korea, South

Subin Kim

Ulsan National Institute of Science and Technology , Korea, South