Chemistry:NMP-7
From HandWiki
Short description: Chemical compound
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| Chemical and physical data | |
| Formula | C23H28N2O |
| Molar mass | 348.490 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
NMP-7 is a drug which acts as both a non-selective agonist of the CB1 and CB2 cannabinoid receptors, and also as a blocker of T-type calcium channels, the target of anticonvulsant drugs such as ethosuximide. NMP-7 has an agonist EC50 of 96.9nM at CB1 and 10.5nM at CB2, and an IC50 of 1.84μM for blocking Cav3.2 T-type calcium channels. In animal studies it produces potent analgesic effects in a variety of different tests.[1]
See also
References
- ↑ "Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands". Molecular Pain 7: 1744-8069-7-89. November 2011. doi:10.1186/1744-8069-7-89. PMID 22093952.
 |  |
