Chemistry:Org 28611
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Short description: Chemical compound
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| Formula | C23H33N3O2 |
| Molar mass | 383.536 g·mol−1 |
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Org 28611 (SCH-900,111) is a drug developed by Organon International which acts as a potent cannabinoid receptor full agonist at both the CB1 and CB2 receptors. It was developed with the aim of finding a water-soluble cannabinoid agonist suitable for intravenous use as an analgesic,[1] and while it achieved this aim and has progressed as far as Phase II clinical trials in humans as both a sedative and an analgesic, results against the comparison drugs (midazolam and morphine respectively) were not particularly favourable in initial testing.[2][3]
See also
References
- ↑ Adam, J. M. (2010). "Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists". MedChemComm (Royal Society of Chemistry) 1: 54. doi:10.1039/c0md00022a.
- ↑ "Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers". Journal of Psychopharmacology 23 (6): 633–44. August 2009. doi:10.1177/0269881108091551. PMID 18635703.
- ↑ A Comparison of Analgesic Efficacy Between a Single Dose of ORG 28611, Morphine, and Placebo After Dental Impaction Surgery
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