What is philosophy of science? Numerous manuals, anthologies or essays provide carefully reconstructed vantage points on the discipline that have been gained through expert and piecemeal historical analyses. In this paper, we address the question from a complementary perspective: we target the content of one major journal of the field—Philosophy of Science—and apply unsupervised text-mining methods to its complete corpus, from its start in 1934 until 2015. By running topic-modeling algorithms over the full-text corpus, we identified 126 key research topics (...) that span across 82 years. We also tracked their evolution and fluctuating significance over time in the journal articles. Our results concur with and document known and lesser-known episodes of the philosophy of science, including the rise and fall of logic and language-related topics, the relative stability of a metaphysical and ontological questioning (space and time, causation, natural kinds, realism), the significance of epistemological issues about the nature of scientific knowledge as well as the rise of a recent philosophy of biology and other trends. These analyses exemplify how computational text-mining methods can be used to provide an empirical large-scale and data-driven perspective on the history of philosophy of science that is complementary to other current historical approaches. (shrink)

One of the most fundamental divides in contemporary philosophy of consciousness is whether phenomenal consciousness requires some form of self-consciousness. More specifically, disagreement revolves around the “Awareness Principle”: For any subject S and conscious mental state M of S, S is aware of M. We call the relevant awareness of one’s own mental states “inner awareness.” While the Awareness Principle (or some idea in the vicinity) was largely accepted by early phenomenologists and early analytic philosophers, it is much more disputed (...) by contemporary philosophers of mind. In this chapter, we offer a bird’s-eye view of philosophical debates surrounding the Awareness Principle. Our goal is to review the main theoretical options available on the market. We open by distinguishing various versions of the Awareness Principle (§1) before addressing the place of inner awareness in the history of philosophy (§2) and in contemporary debates on consciousness (§3). (shrink)

The development of AI tools, such as large language models and speech emotion and facial expression recognition systems, has raised new ethical concerns about AI’s impact on human relationships. While much of the debate has focused on human-AI relationships, less attention has been devoted to another class of ethical issues, which arise when AI mediates human-to-human relationships. This paper opens the debate on these issues by analyzing the case of romantic relationships, particularly those in which one partner uses AI tools, (...) such as ChatGPT, to resolve a conflict and apologize. After reviewing some possible, non-exhaustive, explanations for the moral wrongness of using AI tools in such cases, I introduce the notion of second-person authenticity: a form of authenticity that is assessed by the other person in the relationship (e.g., a partner). I then argue that at least some actions within romantic relationships should respect a standard of authentic conduct since the value of such actions depends on who actually performs them and not only on the quality of the outcome produced. Therefore, using AI tools in such circumstances may prevent agents from meeting this standard. I conclude by suggesting that the proposed theoretical framework could also apply to other human-to-human relationships, such as the doctor-patient relationship, when these are mediated by AI; I offer some preliminary reflections on such applications. (shrink)

In the recent literature, it has been shown that the wave function in the de Broglie–Bohm theory can be regarded as a new kind of field, i.e., a "multi-field", in three-dimensional space. In this paper, I argue that the natural framework for the multi-field is the original second-order Bohm’s theory. In this context, it is possible: i) to construe the multi-field as a real-valued scalar field; ii) to explain the physical interaction between the multi-field and the Bohmian particles; and iii) (...) to clarify the status of the energy-momentum conservation and the dynamics of the theory. (shrink)

Recent trends in psychiatry involve a transition from categorical to dimensional frameworks, in which the boundary between health and pathology is understood as a difference in degree rather than as a difference in kind. A major tenet of dimensional approaches is that no qualitative distinction can be made between health and pathology. As a consequence, these approaches tend to characterize such a threshold as pragmatic or conventional in nature. However, dimensional approaches to psychopathology raise several epistemological and ontological issues. First, (...) we review major sources of evidence usually recruited in support of the dimensional trend (focusing on clinical observation and biological data), and we show that these are connected to different conceptualizations of how dimensional traits extend across health and pathology. Second, we criticize two unquestioned assumptions that stand at the core of the dimensional trend: a) that there is continuity from health to pathology at the symptomatic level; b) that such continuity reflects an underlying continuity in the genetic liability for pathological conditions. Third, we argue against the idea of a conventional threshold by showing that such a view implies a linear relationship between the genotype and the phenotype. Fourth, drawing on epigenetics and developmental biology, we offer a characterization of mental disorders as stable and dynamic constellations of multi-level variables that differ qualitatively from ‘healthy states’. We conclude by showing that our account has several theoretical advantages over both categorical and dimensional approaches. Notably, it provides crucial insights into psychological development over time and individual differences, with major implications in terms of intervention and clinical decision-making. (shrink)

Linguistic data are commonly considered a defeasible source of evidence from which it is legitimate to draw philosophical hypotheses and conclusions. Traditionally epistemologists have relied almost exclusively on linguistic data from western languages, with a primary focus on contemporary English. However, in the last two decades there has been an increasing interest in cross-linguistic studies in epistemology. In this entry, we provide a brief overview of cross-linguistic data discussed by contemporary epistemologists and the philosophical debates they have generated.

Since the 1990s the so-called transparency of experience has played a crucial role in core debates in philosophy of mind. However, recent developments in the literature have made transparency itself quite opaque. The very idea of transparent experience has become quite fuzzy, due to the articulation of many different notions of transparency and transparency theses. Absent a unified logical space where these notions and theses can be mapped and confronted, we are left with an overall impression of conceptual chaos. This (...) is a problem, given the constant and ubiquitous references to transparency in the literature and its prominent position in the contemporary philosophy of mind. My goal in this paper is to restore clarity through proper analysis of the mutual relations between the different transparency theses. This allows me to uncover a unitary multidimensional logical space where existing (as well as possible) views can be properly singled out and located. (shrink)

The paper investigates what type of motivation can be given for adopting a knowledge-based decision theory. KBDT seems to have several advantages over competing theories of rationality. It is commonly argued that this theory would naturally fit with the intuitive idea that being rational is doing what we take to be best given what we know, an idea often supported by appeal to ordinary folk appraisals. Moreover, KBDT seems to strike a perfect balance between the problematic extremes of subjectivist and (...) objectivist decision theory. We argue that these alleged advantages do not stand up to a closer scrutiny: KBDT inherits the same kinds of problems as alternative decision theoretic frameworks but doesn’t retain any of the respective advantages. Moreover, differently from other knowledge-action principles advanced in the literature, KBDT cannot fully explain the intuitive connections between knowledge and rational action. We conclude that the most serious challenge for knowledge-based decision theorists is to provide a substantive rationale for the adoption of such a view. (shrink)

Iglesias et al. (2025) argue that digital twins could serve as tools for achieving certain person-span extension goods, specifically legacy/impact and relational aims. The former pertain to broadly...

This book rethinks procreative responsibility considering the continuous development of Assisted Reproductive Technologies. It presents a person-affecting moral argument, highlighting that the potential availability of future Assisted Reproductive Technologies brings out new procreative obligations. Traditionally, Assisted Reproductive Technologies are understood as practices aimed at extending the procreative freedom of prospective parents. However, some scholars argue that they also give rise to new moral constraints. This book builds on this viewpoint by presenting a person-affecting perspective on the impact of current and (...) future Assisted Reproductive Technologies on procreative responsibility, with a specific focus on reproductive Genome Editing and ectogenesis. The author shows that this perspective is defensible both from a consequences-based person-affecting perspective and from a person-affecting account that considers morally relevant intuitions and attitudes. (shrink)

What is the relation between non-domination and rights in the sense of claim-rights? This article argues that this relation is a tight one: rights turn out to be a necessary constituent of non-domination, or they are necessary, in a non-causal sense, for non-domination to come into existence and have its distinctive normative character. In particular, rights are necessary to constitute the following features of non-domination: the authority that non-domination signifies and the respect it demands; the kind of accountability that the (...) non-arbitrariness condition of non-domination demands; and the robustness of non-domination. The article then suggests that rights, even if necessary for non-domination, are not also sufficient. It concludes by illustrating how the protection of rights often supports, rather than contradicts, other republican aims. (shrink)

What makes any intentional state about something? Call this the Question of Aboutness (QA). In his article, Crane discusses and criticizes Putnam’s argument for the assumption that a plausible theory of intentionality should answer QA. Crane focuses on the crucial premise: the claim that what goes for physical representations goes for mental representations. Accepting such a claim, Crane argues, depends on one’s commitment to physicalism or anti-psychologism, two substantial and controversial assumptions one is not forced to accept. Hence, he concludes, (...) the requirement of answering QA should not be imposed as a constraint on theories of intentionality. In my commentary, I do three things. First, contra Crane, I argue that Putnam’s crucial premise can be accepted regardless of one’s commitment to physicalism or anti-psychologism. Second, I sketch an alternative way of justifying that premise on purely methodological grounds. This leads to an improved version of Putnam’s argument. Third, borrowing Kriegel’s distinction between subjective and objective mental representation, I sketch a way of resisting the improved version of Putnam’s argument. However, I argue, that is not enough to prevent some version of QA from arising. So, an answer to QA (or some version of it) still constrains theories of intentionality. (shrink)

This paper challenges the common assumption that some phenotypic traits are quantitative while others are qualitative. The distinction between these two kinds of traits is widely influential in biological and biomedical research as well as in scientific education and communication. This is probably due to both historical and epistemological reasons. However, the quantitative/qualitative distinction involves a variety of simplifications on the genetic causes of phenotypic variability and on the development of complex traits. Here, I examine three cases from the life (...) sciences that show inconsistencies in the distinction: Mendelian traits, Mendelian diseases, and polygenic mental disorders. I show that these traits can be framed both quantitatively and qualitatively depending, for instance, on the methods through which they are investigated and on specific epistemic purposes. This suggests that the received view of quantitative and qualitative traits has a limited heuristic power—limited to some local contexts or to the specific methodologies adopted. Throughout the paper, I provide directions for framing phenotypes beyond the quantitative/qualitative distinction. I conclude by pointing at the necessity of developing a principled characterisation of what phenotypic traits, in general, are. (shrink)

Procreative obligations are often discussed by evaluating only the consequences of reproductive actions or omissions; less attention is paid to the moral role of intentions and attitudes. In this paper, I assess whether intentions and attitudes can contribute to defining our moral obligations with regard to assisted reproductive technologies already available, such as preimplantation genetic diagnosis (PGD), and those that may be available in future, such as reproductive genome editing and ectogenesis, in a way compatible with person‐affecting constraints. I propose (...) the parent–child relationship argument, which is based on the moral distinction between creating and parenting a child. Hence, I first argue that intentions and attitudes can play a role in defining our moral obligations in reproductive decisions involving PGD. Second, I maintain that if we accept this and recognize reproductive genome editing and ectogenesis as person‐affecting procedures, we should be committed to arguing that prospective parents may have moral reasons to prefer reproduction via such techniques than via sexual intercourse. In both cases, I observe an extension of our procreative responsibility beyond what is proposed by the consequentialist person‐affecting morality. (shrink)

My claim in this article is that the thesis that Buddhism has no God, insofar as it is taken to apply to Buddhism universally, is false. I defend this claim by interpreting a central text in East-Asian Buddhism – The Awakening of Faith in Mahāyāna – through the lenses of perfect being theology (PBT), a research programme in philosophy of religion that attempts to provide a description of God through a two-step process: (1) defining God in terms of maximal greatness; (...) (2) inferring the properties or attributes that God must have in virtue of satisfying the definition. My argument comprises two steps. First, I argue that, since PBT is a method for providing a description of God starting from a definition of God, any text that contains a PBT ipso facto contains a notion of God. Second, I argue through textual evidence that The Awakening articulates a PBT, concluding that it contains a notion of God. Since the method of PBT leaves open what descriptions are to be inferred, my argument allows me to conclude that a text contains a notion of God without previously committing to any particular conception of the divine, which makes it particularly versatile and powerful. (shrink)

This paper puts forward a wish list of requirements for formal fairness in the specific context of triage in emergency departments (EDs) and maps the empirical and conceptual research questions that need to be addressed in this context in the near future. The pandemic has brought to the fore the necessity for public debate about how to allocate resources fairly in a situation of great shortage. However, issues of fairness arise also outside of pandemics: decisions about how to allocate resources (...) are structurally unavoidable in healthcare systems, as value judgements underlie every allocative decision, although they are not always easily identifiable. In this paper, we set out to bridge this gap in the context of EDs. In the first part, we propose five formal requirements specifically applied for ED triage to be considered fair and legitimate: publicity, accessibility, relevance, standardisability and accountability. In the second part of the paper, we map the conceptual and empirical ethics questions that will need to be investigated to assess whether healthcare systems guarantee a formally just ED triage. In conclusion, we argue that there is a vast research landscape in need of an in-depth conceptual and empirical investigation in the context of ED triage in ordinary times. Addressing both types of questions in this context is vital for promoting a fair and legitimate ED triage and for fostering reflection on formal fairness allocative issues beyond triage. (shrink)

This paper offers an original interpretation of the Daodejing 道德經 as containing a distinctive account of creation. In my reading, the Daodejing envisions the creation of the cosmos by Dao (1) as a movement from the absence of phenomenal forms to phenomenal forms and (2) as a movement from nothingness to existence. I interpret creation as a unique metaphysical operation that explains how (1) and (2) are possible. The paper is organized into two sections. First, I introduce the distinctions between (...) the lack and presence of phenomenal forms (§1.1) and between nothingness and existence (§1.2), using them to map the distinction between Dao and the created world. Then, I propose my account of the Daodejing’s metaphysics of creation (§2.1) and elaborate on its connection with the previously drawn distinctions while answering a potential objection (§2.2). I conclude with some considerations about the connections between the Daodejing’s view of creation and its soteriology. (shrink)

Philosophers have become increasingly aware of the difficulties that plague accounts of kinds with objectively determined boundaries, and generally recognise that scientific taxonomies are shaped by human pragmatic interests and non-epistemic values. Against this trend, we propose an account of kinds conceived as dynamic entities, characterised by qualitatively distinct and robust trajectories originating from bifurcation events in the development of complex systems. We argue that the Homeorhetic Dynamic Kinds account (HDK) can be applied to systems investigated in a variety of (...) disciplinary contexts, ranging from biology, medicine, and the social sciences. Shifting the focus from a synchronic (homeostatic) to a dynamic and processual (homeorhetic) perspective, we show that HDK allows a better characterisation of discontinuities among kinds. We then outline its implications for pluralism, particularly how HDK can help us understand how scientific categories are shaped both by ontological aspects of developmental trajectories and by pragmatic, value-laden considerations. (shrink)

Assisted reproductive technologies have greatly increased our control over reproductive choices, leading some bioethicists to argue that we face unprecedented moral obligations towards progeny. Several models attempting to balance the principle of procreative autonomy with these obligations have been proposed. The least demanding is the minimal threshold model (MTM), according to which every reproductive choice is permissible, except creating children whose lives will not be worth living. Hence, as long as the future child is likely to have a life worth (...) living, prospective parents may be allowed to use preimplantation genetic diagnosis (PGD) to select embryos with genetic diseases or disabilities. Assuming a consequentialist person‐affecting view of morality, this paper investigates whether the MTM is an appropriate tool to guide procreative decisions given the continuous development of reproductive genetic technologies. In particular, I consider germline genome editing (GGE) and I argue that its application in human reproduction, unlike PGD, should be conceived as person‐affecting towards future progeny. I claim that even if we assume the plausibility of the MTM within PGD, we are committed to accepting that a greater moral obligation towards progeny should guide procreative decisions if GGE were available. In this case, the MTM should no longer be considered an appropriate instrument to guide procreative choices. Finally, I investigate when we face this greater moral obligation, concluding that it applies only when prospective parents have already engaged in the in vitro fertilization process. (shrink)

In 1976, the Genetics Society of America published a document entitled “Resolution of Genetics, Race, and Intelligence.” This document laid out the Society’s position in the IQ controversy, particularly that on scientific and ethical questions involving the genetics of intellectual differences between human populations. Since the GSA was the largest scientific society of geneticists in the world, many expected the document to be of central importance in settling the controversy. Unfortunately, the Resolution had surprisingly little influence on the discussion. In (...) 1979, William Provine analyzed the possible factors that decreased the impact of the Resolution, among them scientists’ limited understanding of the relationship between science and ethics. Through the analysis of unpublished versions of the Resolution and exchanges between GSA members, I will suggest that the limited impact of the statement likely depended on a shift in the aims of the GSA due to the controversies that surrounded the preparation of the document. Indeed, the demands of the membership made it progressively more impartial in both scientific and political terms, decreasing its potential significance for a wider audience. Notably, the troubled history of the Resolution raises the question of what can make effective or ineffective the communication between scientists and the public—a question with resonance in past and present discussions on topics of social importance. (shrink)

Nowadays, many new agents, structures and dynamics make human rights insecure – think of TNCs or climate change. Yet states as they currently are seem unable to tackle these threats effectively. So what should an appropriate human-rights regime, that is, one that protects them securely and legitimately, look like, today? This article argues that republicanism provides the regime we need: a constitutional demoi-cracy. This new, mixed human-rights regime is a demoicracy for, even if states remain the primary locus where human (...) rights are realised, they bind themselves to a union that governs together the new agents, structures and dynamics that threaten them, without their demoi merging into one global demos. It is constitutional, for this governing together gives rise to a thin but binding supranational apparatus, whose point is, similar to domestic constitutions, to constrain state power over human rights and at the same time to empower states to protect them. (shrink)

Potential perspectivism is the view that what an agent ought to do (believe, like, fear, … ) depends primarily on facts that are potentially available to her. I consider a challenge to this view. Potentially accessible facts do not always agglomerate over conjunction. This implies that one can fail to have relevant access to a set of facts as a whole but have access to proper subsets of it, each of which can support different incompatible responses. I argue that potential (...) perspectivism has no unproblematic answer to the question of what the agent ought to do (believe, like, fear, … ) in such circumstances. (shrink)

This paper aims to clarify some conceptual aspects of decoherence that seem largely overlooked in the recent literature. In particular, I want to stress that decoherence theory, in the standard framework, is rather silent with respect to the description of (sub)systems and associated dynamics. Also, the selection of position basis for classical objects is more problematic than usually thought: while, on the one hand, decoherence offers a pragmatic-oriented solution to this problem, on the other hand, this can hardly be seen (...) as a genuine ontological explanation of why the classical world is position-based. This is not to say that decoherence is not useful to the foundations of quantum mechanics; on the contrary, it is a formidable weapon, as it accounts for a realistic description of quantum systems. That powerful description, however, becomes manifest when decoherence theory itself is interpreted in a realist framework of quantum mechanics. (shrink)

The notion of maximal greatness is arguably part of the very concept of God: something greater than God is not even possible. But how should we understand this notion? The aim of this paper is to provide a Śaivist answer to this question by analyzing the form of theism advocated in the Pratyabhijñā tradition. First, I extract a model of divine greatness, the Hierarchical Model, from Nagasawa’s work "Maximal God". According to the Hierarchical Model, God is that than which nothing (...) could be greater by virtue of being better suited than all other beings in relation to certain great-making properties (§1). I then offer an analysis of the form of theism advocated in the Pratyabhijñā tradition by discussing passages from the works of Somānanda, the founder of the Pratyabhijñā school, and of Utpaladeva, the most prominent of Somānanda’s disciples. I argue that the Pratyabhijñā theist cannot account for divine greatness in terms of the Hierarchical Model. My argument is that the Hierarchical Model requires a comparison between God and other beings that cannot be made with the Pratyabhijñā God (§2). Finally, I develop an original alternative model, the Unlimited Nature Model, that accounts for God’s maximal greatness in a way that suits Pratyabhijñā’s theism. According to the Unlimited Nature Model, the nature of all ordinary beings is metaphysically limited as a result of realizing only a small portion of the potential of what could be, and God is maximally great because only he has a completely unlimited nature (§3). (shrink)

According to the Rational Threshold View, a rational agent believes p if and only if her credence in p is equal to or greater than a certain threshold. One of the most serious challenges for this view is the problem of statistical evidence: statistical evidence is often not sufficient to make an outright belief rational, no matter how probable the target proposition is given such evidence. This indicates that rational belief is not as sensitive to statistical evidence as rational credence. (...) The aim of this paper is twofold. First, we argue that, in addition to playing a decisive role in rationalizing outright belief, non-statistical evidence also plays a preponderant role in rationalizing credence. More precisely, when both types of evidence are present in a context, non-statistical evidence should receive a heavier weight than statistical evidence in determining rational credence. Second, based on this result, we argue that a modified version of the Rational Threshold View can avoid the problem of statistical evidence. We conclude by suggesting a possible explanation of the varying sensitivity to different types of evidence for belief and credence based on the respective aims of these attitudes. (shrink)

In this paper, we aim at rethinking the concept of obesity in a way that better captures the connection between underlying medical aspects, on the one hand, and an individual’s developmental history, on the other. Our proposal rests on the idea that obesity is not to be understood as a phenotypic trait or character; rather, obesity represents one of the many possible states of a more complex phenotypic trait that we call ‘energy metabolism.’ We argue that this apparently simple conceptual (...) shift can help solve important theoretical misconceptions regarding the genetics, epigenetics, and development of obesity. In addition, we show that our proposal can be fruitfully paired with the concept of developmental channeling of a trait, which connects to the study of the plasticity and canalization of complex traits. Finally, we discuss the potential impact of our approach on the assessment, treatment, and social narratives of obesity. (shrink)

The paper explains why the de Broglie–Bohm theory reduces to Newtonian mechanics in the macroscopic classical limit. The quantum-to-classical transition is based on three steps: (i) interaction with the environment produces effectively factorized states, leading to the formation of _effective wave functions_ and hence _decoherence_; (ii) the effective wave functions selected by the environment—the pointer states of decoherence theory—will be well-localized wave packets, typically Gaussian states; (iii) the quantum potential of a Gaussian state becomes negligible under standard classicality conditions; therefore, (...) the effective wave function will move according to Newtonian mechanics in the correct classical limit. As a result, a Bohmian system in interaction with the environment will be described by an effective Gaussian state and—when the system is macroscopic—it will move according to Newtonian mechanics. (shrink)

This chapter focuses on the controversies surrounding the transparency of experience (or simply transparency), an (alleged) introspective datum that has played a central role in debates on the nature of perceptual experience and phenomenal consciousness. The main emphasis is on issues arising in relation to transparency and introspection, though its significance for the metaphysics of experience is also stressed. First, the chapter outlines Harman’s and Tye’s characterization of transparency and the conclusions they draw about the metaphysics of experience. Next, it (...) discusses the relation between this characterization and introspection by addressing two central questions: first, what picture of introspection is suggested by Harman’s and Tye’s transparency thesis? Second, does introspection genuinely support this thesis? The discussion reveals that Harman’s and Tye’s characterization of transparency relies on substantial and controversial theoretical assumptions that go beyond what can be established on purely (or largely) introspective grounds. In this way, the chapter highlights the main points of disagreement about transparency and, when relevant, their implications for the metaphysics of experience. It concludes by sketching a way of structuring the debate and raising further questions about the genuine pre-theoretical core of transparency and why theoretical supplementation plays such a pivotal role. (shrink)

A widespread (and often tacit) assumption is that fear is an anticipatory emotion and, as such, inherently future-oriented. Prima facie, such an assumption is threatened by cases where we seem to be afraid of things in the past: if it is possible to fear the past, then fear entertains no special relation with the future—or so some have argued. This seems to force us to choose between an account of fear as an anticipatory emotion (supported by pre-theoretical intuitions as well (...) as empirical research in psychology) and admitting cases of past-oriented fear. In this paper, we argue for a proposal that dissolves this dilemma. Our claim is: with the right account in place, the future-orientation of fear can be made compatible with, and is actually explanatory of, cases where we are genuinely afraid of something in the past. So, there is no need to choose: fear is still future-oriented, even when we are genuinely afraid of things in the past. The key is a correct understanding of what fear’s temporal orientation amounts to, and the framework we offer here provides us with such an understanding. (shrink)

Intelligence is one of the most influential yet contested constructs in psychology. Psychometric research, beginning with early intelligence testing and the proposal of a general factor of intelligence, established influential models that continue to shape scientific and applied work. Yet competing theories, challenging the focus on abstract reasoning, highlight ongoing disputes about the nature of intelligence and the assessment of intellectual differences among individuals. Central debates concern the relationship between measurement and theory and the ontological status of the g factor (...) - particularly whether intelligence is reducible to neurocognitive processes or must be treated as an emergent phenomenon. Contemporary research is marked by ontological and epistemological pluralism, reflecting divergent explanatory aims and practical needs. This pluralism also carries normative implications, as different conceptions of intelligence guide educational practices, inform policy, and shape broader societal understandings of human cognitive abilities. (shrink)

In this paper, I analyze the ethical implications of genetic enhancement within the specific framework of the “child’s right to an open future” argument (CROF). Whilst there is a broad ethical consensus that genetic modifications for eradicating diseases or disabilities are in line with – or do not violate – CROF, there is huge disagreement about how to ethically understand genetic enhancement. Here, I analyze this disagreement and I provide a revised formulation of the argument in the specific field of (...) genetic enhancement. First, I argue that CROF is not in contrast with every kind of enhancement. I subsequently discuss whether CROF requires some moral obligations to enhance progeny. My argument is that parents do not have the moral obligation to open as many options as possible for their children. Rather, they should provide them with a reasonable range of opportunities. Finally, I contend that the moral obligations required by CROF are directly dependent on what Allen Buchanan calls the ‘dominant cooperative framework’ in a given society. I conclude by claiming that, at present, parents are not morally obliged to genetically enhance their children since a non-enhanced person already might have access to a reasonable range of opportunities. However, the moral obligation to enhance progeny might arise if a structural modification of the dominant cooperative framework occurs. (shrink)

At the height of the Covid pandemic, there was much discussion in the literature about using human challenge trials (HCTs) to expedite the development of effective Covid-19 vaccines. Historically, reluctance to fully accept HCTs has largely been due to potential conflicts with the principle of nonmaleficence in bioethics. Only a few commentators have explored this topic in depth. In this paper, we claim that to address ethical concerns regarding HCTs, two types of ethical reasons should be identified and investigated: first-order (...) reasons that can be given to claim that a practice in itself is in direct conflict with the principles of bioethics; and second-order reasons that take into consideration how a practice is carried out and its consequences. We argue that understanding these ethical reasons is crucial for guiding the implementation of HCTs. We investigate a first-order reason against HCTs when the practice is in conflict with the principle of nonmaleficence, and when it is not. Following this argument and assuming there is no first-order reason based on nonmaleficence that hinders using HCTs, we argue there may be second-order reasons to guide implementation of this practice, such as difficulty in obtaining informed consent; protection of the weaker party; and trust in the scientific enterprise. (shrink)

In this paper, we discuss the inherent temporal orientation of fear, a matter on which philosophers seem to have contrasting opinions. According to some, fear is inherently present-oriented; others instead maintain that it is inherently future-oriented or that it has no inherent temporal orientation at all. Despite the differences, however, all these views seem to understand fear’s temporal orientation as one-dimensional—that is, as uniquely determined by the represented temporal location of the intentional object of fear. By contrast, we present a (...) view that introduces a two-dimensional account of fear’s temporal orientation. On such a view, we can say that fear is inherently future-oriented, independently of its being about something in the present or in the future. (shrink)

This paper aims to clarify the opposition between Alexander of Aphrodisias, followed by Hermann Bonitz on one side, and Thomas Aquinas, followed by Lambertus Marie de Rijk on the other, regarding the correct reading of an example proposed by Aristotle in Metaphysics V 7, 1017a 34–35, which involves the diagonal and its incommensurability with the side. The author aims to demonstrate that Aquinas’s interpretation (and De Rijk’s one) cannot be accepted and that we should follow Alexander of Aphrodisias and Bonitz.

Structuralism, as I will use the term, is the view that phenomenal character is fully determined by the similarity relations between experiences – that, for instance, the way an orange experience feels is entirely a matter of its relational profile within the space of color experiences. This theory has been criticized because it seems to leave out what is sometimes referred to as the intrinsic character of experience. However, these critiques have failed to convince numerous scholars, largely due to their (...) reliance on intuition, a tool that many consider unreliable. Here, I present two objections to structuralism that rest on firmer ground. The starting point is certain structural features of color experience that are widely accepted in the science and philosophy of color, despite some criticisms that I discuss and reject. Then, playing the structuralist game through and through, I defend the claim that the structure of color experience is incompatible with structuralism, which is ironic if one considers that structuralism should be expected to account at least for the structural features of experience. I formulate two arguments to show this incompatibility: one focusing on the unique hues (red, green, yellow, and blue), and a second focusing on the rule regulating how the pure colors (red, green, yellow, blue, black, and white) combine in the composite colors. I consider some possible counterarguments, provide rebuttals, and conclude that structuralism should be rejected. (shrink)

What is owed to individuals who find themselves in a stateless condition? This paper ad-dresses this question by providing a novel republican account of the human right to legal citizenship. I argue that such individuals are owed citizenship, and that this duty corre-sponding to their human right to legal citizenship falls primarily on the entire international community, and only derivatively on single states. I then show that those owed citizen-ship as a matter of human rights are not only the formally (...) stateless, but also, surprisingly, refugees, some displaced people and, arguably, some long-term migrants, too. This view improves the literature on human rights by showing that the standard view of states as primary duty-bearers, and international institutions as secondary duty-bearers only, needs improvement, for some duties correlated with human rights are primarily international. It also advances the debate in the political theory of migration on the duty to naturalize the formally and de facto stateless by clarifying this duty’s nature, grounds, scope, interna-tional dimension and implications. (shrink)

Volume 24, Issue 8, August 2024, Page 60-62.

The structural scarcity of healthcare resources has deeply challenged their fair distribution, prompting the need for allocation criteria. Long under the spotlight of the bioethical debate with an extraordinary peak during the recent COVID-19 pandemic, micro-allocation of healthcare has been extensively discussed in the literature with regard to issues of substantive and formal justice. This paper addresses a relatively underdiscussed question within the field of formal justice: who should define micro-allocation criteria in healthcare? To explore this issue, we first establish (...) formal requirements that must be met for allocation criteria to be considered fair and legitimate. Then, we introduce three possible answers to the research question: the attending physician, the team of physicians, and the team of experts. We discuss and then reject all of them, arguing that the task of defining allocation criteria should be assigned to a political representative, supported by a cross-disciplinary team of experts. This proposal is based on the need to take democracy seriously as a tool for making substantive allocative decisions in light of the inevitable disagreement on such matters within a community. To support this claim, we present two key arguments—the democracy argument and the consistency argument. We also pre-emptively respond to two significant critiques: the too-specificity of the decision critique and the catastrophic outcomes critique. In conclusion, we argue that our proposal offers the fairest and most legitimate decision-making process for healthcare micro-allocation. (shrink)

Eating Disorders (EDs) raise significant challenges from a diagnostic and nosological perspective. Much of this is due to the extensive overlap among diagnostic criteria, with symptoms being shared by several conditions and subtypes. This nosological uncertainty is further exacerbated by two additional features of EDs, which will be the focus of this paper, namely diagnostic crossover and recovery. First, patients who acquire or lose one or more symptoms over time (symptom shifting) often transition to a new diagnostic category (crossover). Second, (...) researchers working on EDs have recently underscored a problematic lack of inclusion of patients’ perspective on diagnostic and recovery processes, which results in an incomplete understanding of key aspects of EDs. Drawing on theoretical frameworks and concepts from Dynamical Systems Theory and epigenetics, we present a dynamic characterization of EDs that allows us to tackle the challenges of crossover and recovery. In our framework, different conditions represent robust endpoints in individuals’ developmental trajectories that are nonetheless flexible in certain circumstances. Thinking about EDs in diachronic terms also prompts us to significantly reframe our notion of recovery, not so much as the return to health but as the generation of future healthy trajectories, to be pursued in compliance with patients’ self-perception and aims. Indeed, the key role of patients’ values in determining their future trajectories testifies how psychiatric categories are not merely descriptive but constitutive, influencing both self-understanding and clinical practice. (shrink)

The structural scarcity of healthcare resources raises im- portant bioethical issues regarding their allocation, such as who should make such decisions. This paper evaluates whether or not physicians should be responsible for deciding how to allocate healthcare resources in the micro-allocation context. Addressing this issue is essential for determining the moral or legal responsibility of physicians when allocating scarce healthcare resources in both ordinary and emer- gency conditions. The paper is structured as follows: First, I discuss the perspective of the (...) physician as a double agent, balancing their duty to their patient with that towards other patients and society. This perspective aims to justify bedside rationing by physicians. After discussing some critical issues with this conception, I propose a critique based of the prin- ciple of justice. I then define the necessary requirements for a fair and legitimate allocation choice in healthcare and argue that the specificity of such a choice makes it morally problematic to attribute a direct decision-making role to the treating physician when rationing healthcare resources in the micro-allocation context. This leads to a rejection of the conception of the physician as a double agent and bedside rationing, although I observe that this does not preclude the physician from some involvement in the process of defining allocation criteria and methods. (shrink)

Heterogeneous treatment effects represent a major issue for medicine as they undermine reliable inference and clinical decision-making. To overcome the issue, the current vision of precision and personalized medicine acknowledges the need to control individual variability in response to treatment. In this paper, we argue that gene-treatment-environment interactions (G × T × E) undermine inferences about individual treatment effects from the results of both genomics-based methodologies—such as genome-wide association studies (GWAS) and genome-wide interaction studies (GWIS)—and randomized controlled trials (RCTs). Then, (...) we argue that N-of-1 trials can be a solution to overcome difficulties in handling individual variability in treatment response. Although this type of trial has been suggested as a promising strategy to assess individual treatment effects, it nonetheless has limitations that limit its use in everyday clinical practice. We analyze the existing variability within the designs of N-of-1 trials in terms of a continuum where each design prioritizes epistemic and pragmatic considerations. We then support wider use of the designs located at the pragmatic end of the explanatory-pragmatic continuum. (shrink)

Obligations can be affected by knowledge. Several approaches exist to formalize knowledge-based obligations, but no formalism has been developed yet to capture the dynamic interaction between knowledge and obligations. We introduce the dynamic extension of an existing logic for knowledge-based obligations here. We motivate the logic by analyzing several scenarios and by showing how it can capture in an original manner several fundamental deontic notions such as absolute, prima facie and all-things-considered obligations. Finally, in the dynamic epistemic logic tradition, we (...) provide reduction axioms for the dynamic operator of the new logic. (shrink)

In this paper, I discuss the concept of phenomenological data by analyzing it in comparison with neurophenomenology and similar approaches that employ qualitative tools in empirical studies. I argue that although such data are often labeled as “phenomenological,” they do not meet the epistemological criteria of phenomenology properly understood. I distinguish the epistemological concept of consciousness (pure consciousness) from the psychological concept of the Self (empirical consciousness), and then suggest that neurophenomenology and related approaches are primarily focused on the Self. (...) As a result, they fail to engage with consciousness as originally conceived by Husserl. After briefly introducing the core principles of phenomenology to demonstrate its focus on the universal structures of consciousness, I apply them to interpret two neurophenomenological experiments, so as to reveal the underlying epistemological difference. I identify contingent or empirical elements that are implicitly introduced into these experimental designs, which cannot be defined as universal or invariant. Based on these considerations, I propose that the pure level of analysis, characteristic of phenomenology, is more closely aligned with mainstream cognitive neuroscience than with neurophenomenology and qualitative methods. Finally, I will draw upon the previous discussions to propose an epistemological shift in experimental studies. New insights into the universal processing of consciousness are proposed as a more robust approach to investigating the universal brain processing. Keywords: Essences, Cognitive Neuroscience, Phenomenology, Neurophenomenology,. (shrink)

"La struttura delle rivoluzioni scientifiche", dopo più di mezzo secolo dalla sua pubblicazione, è ancora in grado di offrire un contributo alla pratica filosofica? In questo articolo, attraverso i concetti peirceani di Abito, Abduzione e Verità, si propone una lettura pragmaticista del testo di Kuhn che intende rilanciare un fecondo confronto, ancora poco considerato, tra i due filosofi.

ITA: In questo articolo analizzerò la differenza tra il concetto di ereditarietà e quello di ereditabilità. In primo luogo, evidenzierò come i due concetti derivino storicamente da differenti tradizioni nello studio della variabilità fenotipica e del rapporto genotipo-fenotipo. Secondariamente, illustrerò gli aspetti teorici e metodologici alla base dei due concetti, che sono peraltro collegati a differenti aree delle scienze biologiche. Infine, spiegherò brevemente come si sia recentemente tentato, con molte difficoltà, di connettere lo studio dei meccanismi dell’ereditarietà allo studio dell’ereditabilità. (...) Nel discutere le questioni di cui sopra, farò riferimento a tratti psicologici come l’intelligenza dal momento che è proprio dallo studio di questo tipo di tratti che sono emersi i maggiori problemi teorici e metodologici, nonché le controversie più intense. -/- ENG: In this paper, I analyse the distinction between heredity and heritability. First, I highlight that the two concepts derive from different historical traditions in the study of phenotypic variability and of the genotype-phenotype relationship. Second, I illustrate the theoretical and methodological aspects connected to the two concepts, which are traditionally associated with different areas of biological research. Then, I focus on recent attempts aimed at connecting with each other the analysis of heredity and of heritability. In my discussion, I shall often refer to human psychological traits such as intelligence. Indeed, most theoretical and methodological discussions have emerged with respect to the study of these traits. (shrink)

Questo contributo propone una riflessione sul tema dell’expertise bioetica. In primo luogo, si definirà questo tipo di expertise come una competenza metodologica. Questa scelta è motivata dalla necessità di rispondere alla critica secondo cui non potrebbe esistere l’expertise in ambito bioetico. In secondo luogo, si sosterrà che definire tale exper- tise in termini metodologici non basta per esaurire la riflessione sul tema; verranno dunque accennate alcune questioni da affrontare per una definizione completa in questo ambito.

Research in pharmacogenomics and precision medicine has recently introduced the concept of Polygenic Scores (PGSs), namely, indexes that aggregate the effects that many genetic variants are predicted to have on individual disease risk. The popularity of PGSs is increasing rapidly, but surprisingly little attention has been paid to the idealisations they make about phenotypic development. Indeed, PGSs rely on quantitative genetics models and methods, which involve considerable theoretical assumptions that have been questioned on various grounds. This comes with epistemological and (...) ethical concerns about the use of PGSs in clinical decision-making. In this paper, I investigate to what extent idealisations in genetics models can impact the data gathering and clinical interpretation of genomics findings, particularly the calculation and predictive accuracy of PGSs. Although idealisations are considered ineliminable components of scientific models, they may be legitimate or not depending on the epistemic aims of a model. I thus analyse how various idealisations have been introduced in classical models and progressively readapted throughout the history of genetic theorising. Notably, this process involved important changes in the epistemic purpose of such idealisations, which raises the question of whether they are legitimate in the context of contemporary genomics. (shrink)

Newborn screening is a publicly funded test aimed at identifying genetic diseases in healthy infants where early diagnosis can lead to timely and effective clinical intervention. Recently, there has been growing interest in applying genomic sequencing, in particular Whole Genome Sequencing and Whole Exome Sequencing, to this screening, significantly increasing the number of identifiable conditions. Considering the promises of this approach and the specificity of genomic data, some have suggested that newborn sequencing could serve the interests of not only screened (...) newborns but also their parents, relatives, and even society. Determining which interests should legitimately be considered in genomic newborn sequencing is crucial for defining which genes to include in the gene panel of neonatal genomic screening. Stemming from a bioethical perspective, this paper discusses which interests should be considered in newborn sequencing, what the implications are for gene panel definition, and what conflicts between interests might emerge. Specifically, the newborn clinical interest, the reproductive interest, the family clinical interest, personal utility, and social utility will be considered. (shrink)

In recent years, a trend in AI research has started to pursue human-level, general artificial intelli-gence (AGI). Although the AGI framework is characterised by different viewpoints on what intelligence is and how to implement it in artificial systems, it conceptualises intelligence as flexible, general-purposed, and capable of self-adapting to different contexts and tasks. Two important ques-tions remain open: a) should AGI projects simu-late the biological, neural, and cognitive mecha-nisms realising the human intelligent behaviour? and b) what is the relationship, if (...) any, between the concept of general intelligence adopted by AGI and that adopted by psychometricians, i.e., the g factor? In this paper, we address these ques-tions and invite researchers in AI to open a dis-cussion on the theoretical conceptions and practi-cal purposes of the AGI approach. (shrink)

In this paper, building on these previous works, we propose to go deeper into the understanding of crowd behavior by proposing an approach which integrates ontologi- cal models of crowd behavior and dedicated computer vision algorithms, with the aim of recognizing some targeted complex events happening in the playground from the observation of the spectator crowd behavior. In order to do that, we first propose an ontology encoding available knowledge on spectator crowd behavior, built as a spe- cialization of the (...) DOLCE foundational ontology, which allows the representation of categories belonging both to the physical and to the social realms. We then propose a simplified and tractable version of such ontology in a new temporal extension of a description logic, which is used for temporally coupling events happening on the play- ground and spectator crowd behavior. At last, computer vision algorithms provide the input information concerning what is observed on the stands and ontological reasoning delivers the output necessary to perform complex event recognition. (shrink)