Biology:HIVEP1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.

Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]

Further reading

• "High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1". Biochemistry 31 (16): 3907–17. 1992. doi:10.1021/bi00131a004. PMID 1567844. 
• "Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes". Mol. Cell. Biol. 10 (7): 3700–8. 1990. doi:10.1128/mcb.10.7.3700. PMID 1694016. 
• "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products". J. Virol. 66 (1): 244–50. 1992. doi:10.1128/JVI.66.1.244-250.1992. PMID 1727488. 
• "A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence". Genes Dev. 4 (1): 29–42. 1990. doi:10.1101/gad.4.1.29. PMID 2106471. 
• "A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes". Mol. Cell. Biol. 10 (4): 1406–14. 1990. doi:10.1128/mcb.10.4.1406. PMID 2108316. 
• "High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution". Biochemistry 29 (40): 9324–34. 1991. doi:10.1021/bi00492a004. PMID 2248949. 
• "Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1". J. Biol. Chem. 264 (25): 14591–3. 1989. doi:10.1016/S0021-9258(18)63733-0. PMID 2504707. 
• "Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa B". J. Med. Chem. 38 (17): 3264–70. 1995. doi:10.1021/jm00017a011. PMID 7650680. 
• "Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression". J. Virol. 68 (2): 1002–9. 1994. doi:10.1128/JVI.68.2.1002-1009.1994. PMID 8289330. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748. 
• "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B. 
• "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. 2006. doi:10.1093/nar/gkl105. PMID 16582099. 
• "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 

External links

• HIVEP1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.