Biology:ZNF217

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Zinc finger protein 217, also known as ZNF217, is a protein which in humans is encoded by the ZNF217 gene.

Function

ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy. Znf217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression.

See also

• Zinc finger

Further reading

• "Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1775 (2): 333–40. Jun 2007. doi:10.1016/j.bbcan.2007.05.001. PMID 17572303. https://escholarship.org/uc/item/76n9g53w. 
• "Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization". Proceedings of the National Academy of Sciences of the United States of America 91 (6): 2156–60. Mar 1994. doi:10.1073/pnas.91.6.2156. PMID 8134364. Bibcode: 1994PNAS...91.2156K. 
• "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proceedings of the National Academy of Sciences of the United States of America 95 (15): 8703–8. Jul 1998. doi:10.1073/pnas.95.15.8703. PMID 9671742. Bibcode: 1998PNAS...95.8703C. 
• "The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells". Cancer Research 61 (4): 1250–4. Feb 2001. PMID 11245413. 
• "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry 278 (9): 7234–9. Feb 2003. doi:10.1074/jbc.M208992200. PMID 12493763. 
• "Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization". The Journal of Pathology 200 (3): 320–6. Jul 2003. doi:10.1002/path.1359. PMID 12845628. 
• "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. Aug 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B. 
• "Detection of Her2/neu, c-MYC and ZNF217 gene amplification during breast cancer progression using fluorescence in situ hybridization". Oncology Reports 13 (4): 633–41. Apr 2005. doi:10.3892/or.13.4.633. PMID 15756435. 
• "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction". Human Molecular Genetics 14 (21): 3219–25. Nov 2005. doi:10.1093/hmg/ddi352. PMID 16203743. 
• "Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins". Molecular and Cellular Biology 26 (21): 8159–72. Nov 2006. doi:10.1128/MCB.00680-06. PMID 16940172. 
• "Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence". Oncogene 26 (23): 3378–86. May 2007. doi:10.1038/sj.onc.1210126. PMID 17130829. 

External links

• ZNF217+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)