Biology:MNX1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Motor neuron and pancreas homeobox 1 (MNX1), also known as Homeobox HB9 (HLXB9), is a human protein encoded by the MNX1 gene.[1]
Clinical significance
Mutations in the MNX1 gene are associated with Currarino syndrome.[2] Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer.[3]
References
- ↑ "Entrez Gene: HLXB9 homeobox HB9". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3110.
- ↑ "Novel MNX1 mutations and clinical analysis of familial and sporadic Currarino cases". Eur J Med Genet 56 (12): 648–54. 2013. doi:10.1016/j.ejmg.2013.09.011. PMID 24095820.
- ↑ Zhang, W., Huang, L., Lu, X., Wang, K., Ning, X., & Liu, Z. (2019). Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer. Bosnian journal of basic medical sciences, 19(2), 164–171. https://doi.org/10.17305/bjbms.2019.3713
Further reading
- "Genetic control of caudal development". Clin. Genet. 61 (2): 89–96. 2002. doi:10.1034/j.1399-0004.2002.610202.x. PMID 11940082.
- "Nucleotide sequence of a novel diverged human homeobox gene encodes a DNA binding protein". Nucleic Acids Res. 19 (13): 3742. 1991. doi:10.1093/nar/19.13.3742. PMID 1677181.
- "Selective expression of two homeobox genes in CD34-positive cells from human bone marrow". Blood 78 (2): 323–8. 1991. doi:10.1182/blood.V78.2.323.323. PMID 1712647.
- "A gene for autosomal dominant sacral agenesis maps to the holoprosencephaly region at 7q36". Nat. Genet. 11 (1): 93–5. 1995. doi:10.1038/ng0995-93. PMID 7550324.
- "A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues". J. Biol. Chem. 269 (31): 19968–75. 1994. doi:10.1016/S0021-9258(17)32115-4. PMID 7914194.
- "A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis". Nat. Genet. 20 (4): 358–61. 1998. doi:10.1038/3828. PMID 9843207.
- "A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36". Genomics 57 (3): 342–51. 1999. doi:10.1006/geno.1999.5796. PMID 10329000.
- "Involvement of the HLXB9 homeobox gene in Currarino syndrome". Am. J. Hum. Genet. 66 (1): 312–9. 2000. doi:10.1086/302723. PMID 10631160.
- "Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene". Am. J. Hum. Genet. 66 (5): 1504–15. 2000. doi:10.1086/302899. PMID 10749657.
- "Spectrum of mutations and genotype-phenotype analysis in Currarino syndrome". Eur. J. Hum. Genet. 9 (8): 599–605. 2001. doi:10.1038/sj.ejhg.5200683. PMID 11528505.
- "HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3". Leukemia 19 (5): 841–6. 2005. doi:10.1038/sj.leu.2403716. PMID 15772702.
- "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science 308 (5725): 1149–54. 2005. doi:10.1126/science.1108625. PMID 15790807. Bibcode: 2005Sci...308.1149C.
- "Differentiation of insulin-producing cells from human neural progenitor cells". PLOS Med. 2 (4): e103. 2005. doi:10.1371/journal.pmed.0020103. PMID 15839736.
- "Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays". Genome Res. 15 (7): 987–97. 2005. doi:10.1101/gr.3455305. PMID 15998911.
- "High incidence of t(7;12)(q36;p13) in infant AML but not in infant ALL, with a dismal outcome and ectopic expression of HLXB9". Genes Chromosomes Cancer 45 (8): 731–9. 2006. doi:10.1002/gcc.20335. PMID 16646086.
- "Clinical and genetic analysis of HLXB9 gene in Korean patients with Currarino syndrome". J. Hum. Genet. 52 (8): 698–701. 2007. doi:10.1007/s10038-007-0173-y. PMID 17612791.
External links
- MNX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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