Biology:ZNF74
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Zinc finger protein 74 is a protein that in humans is encoded by the ZNF74 gene.[1][2][3] Schizophrenia susceptibility has been associated with a mutation in this protein.[4]
Interactions
ZNF74 has been shown to interact with POLR2A.[5]
References
- ↑ "Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2)". Genomics 13 (3): 641–8. August 1992. doi:10.1016/0888-7543(92)90135-F. PMID 1639391.
- ↑ "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. December 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- ↑ "Entrez Gene: ZNF74 zinc finger protein 74". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7625.
- ↑ Takase, K.; T. Ohtsuki; O. Migita; M. Toru; T. Inada; K. Yamakawa-Kobayashi; T. Arinami (1 December 2001). "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia". Schizophrenia Research 52 (3): 161–165. doi:10.1016/s0920-9964(00)00191-2. PMID 11705709.
- ↑ "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. 272 (44): 27877–85. October 1997. doi:10.1074/jbc.272.44.27877. PMID 9346935.
Further reading
- "Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome". Hum. Mol. Genet. 2 (10): 1583–7. 1994. doi:10.1093/hmg/2.10.1583. PMID 8268910.
- "The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix". J. Biol. Chem. 271 (26): 15458–67. 1996. doi:10.1074/jbc.271.26.15458. PMID 8663113.
- "Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit". J. Biol. Chem. 272 (44): 27877–85. 1997. doi:10.1074/jbc.272.44.27877. PMID 9346935.
- "ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human neural crest-derived tissues and foregut endoderm epithelia". Genomics 62 (1): 82–5. 2000. doi:10.1006/geno.1999.5982. PMID 10585771.
- "Alternative promoter usage and splicing of ZNF74 multifinger gene produce protein isoforms with a different repressor activity and nuclear partitioning". DNA Cell Biol. 20 (3): 159–73. 2001. doi:10.1089/104454901300069004. PMID 11313019.
- "Association of ZNF74 gene genotypes with age-at-onset of schizophrenia". Schizophrenia Research 52 (3): 161–5. 2001. doi:10.1016/S0920-9964(00)00191-2. PMID 11705709.
- "Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells". J. Biol. Chem. 278 (25): 22367–73. 2003. doi:10.1074/jbc.M302234200. PMID 12684500.
- "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. 2005. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
External links
- ZNF74+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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